Deploying a multi-locus TMS device in a clinical environment

Abstract Multi-locus transcranial magnetic stimulation (mTMS) is an emerging technology that uses multiple overlapping coils to spatially manipulate the profile of induced electric field on cortex, based superposition principle. Instead physically moving transducer, location can be electronically adjusted millimeter and millisecond scales. Previously, we have demonstrated this in a research environment. Next, will provide one mTMS device for safe use clinical setting. Our new contains five independent channels therefore able drive simultaneously. The system field-programmable gate array (FPGA) core, similar our previous devices. To accomplish transition, introduced layers safety both software hardware side. designed inherently at least single-fault safe, is, two or more failures must occur before there malfunction poses any risk. also transmits monitors periodic heartbeat messages between its subsystems, indicating proper operation. microcontrollers inside cabinet monitor various internal fault conditions, as well external events, such corrupted data packets missing heartbeats. If safety-critical occurs, disable device. Defensive programming practices were used design software. However, it difficult produce completely error-free code, are parallel with dedicated emergency hardware. We built accompanying five-coil which follows medical regulations means patient protection robust exterior. In addition, transducer integrated memory storing coil-related data, unique identifier each coil prevent unauthorized coils. latest enables safer-than-before Research Category Technology Methods Translational Research: 10. Transcranial Magnetic Stimulation (TMS) Keywords: mTMS, clinical, safety,